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What characterizes the symptoms of Prader-Willi Syndrome?

  1. Persistent muscle weakness

  2. Overeating and obesity

  3. Mental health disorders

  4. Severe motor deficits

The correct answer is: Overeating and obesity

The symptoms of Prader-Willi Syndrome are primarily characterized by a constant feeling of hunger leading to overeating and subsequent obesity. This condition stems from an imbalance in the hypothalamus, which regulates appetite, making individuals with Prader-Willi Syndrome unable to feel satisfied after eating. Individuals with this syndrome often exhibit a strong drive to eat, regardless of their nutritional status, which can lead to significant weight gain and associated health complications. Overeating typically manifests during early childhood, where affected children display an inability to regulate their food intake, contributing to excessive body weight later in life. While other symptoms such as mild intellectual disabilities, social and emotional challenges, and physical issues can accompany Prader-Willi Syndrome, the hallmark feature is the insatiable appetite leading to obesity. This distinguishes it from other conditions that might also present with muscle weakness, mental health disorders, or motor difficulties but do not share this critical symptom of extreme hunger and its consequences.